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1994-10-25
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Document 2950
DOCN M94A2950
TI Clinical significance of hyperamylasemia in HIV patients.
DT 9412
AU Merino E; Reus S; Sanchez J; Trigo C; Boix V; Portilla J; Perez-Mateo M;
Hospital General Universitario de Alicante, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):188 (abstract no. PB0181). Unique
Identifier : AIDSLINE ICA10/94369625
AB OBJECTIVE: To investigate the origin and clinical significance of
hyperamylasemia in HIV patients. METHODS: We have studied HIV patients
with hyperamylasemia (> 220UI/L) admitted at our unit between Oct-92 and
Jan-94. We investigated history of pancreatitis, alcohol intake and
previous drugs. Liver and renal function tests, serum lipase (lip),
pancreatic isoamylasa (iso), immunoreactive trypsin (tryp) levels and
macroamylasemia (mac) were investigated. Alteration pancreatic
morphology (alt morp) was evaluated by ultrasound and/or CT abdominal
scanning. RESULTS: We found 24 patients (7.8%) with hyperamylasemia.
Mean age 32.6 years, 20 were IVDU. Clinical stage, A3: 1 case, B2: 2,
B3: 1 and C3: 20 (83%). Six patients had alcohol intake > 40g/day, and
nobody with previous pancreatitis. Three patients took ddI, 4 inhaled
monthly pentamidine and 16 TMP-SFX (9 for prophylaxis and 7 for PCN
treatment). Four cases presented mild increasing in serum creatinine
(2.3 mg/dl) and 60% had liver enzymes elevated. We made two groups,
those with at least another pancreatic enzyme increased (group I), and
those with isolated hyperamylasemia (group II). We didn't find relation
with any treatment or opportunistic infection. TABULAR DATA, SEE
ABSTRACT VOLUME. CONCLUSIONS: 1) Asymptomatic hyperamilasemia can appear
in advanced HIV infection and most of them (87%) are of pancreatic
origin. 2) Pancreatic morphology is often altered. 3) Subclinic
pancreatitis in aids is not always drug-related. 4) Hyperamilasemia of
saliva origin appears in HIV patients with less immunodeficiency.
DE Alcoholism/COMPLICATIONS/*ENZYMOLOGY Amylases/*BLOOD Diagnostic
Imaging Human HIV Infections/*ENZYMOLOGY Kidney Function Tests Liver
Function Tests Pancreas/PATHOLOGY Pancreatic Function Tests
Pancreatitis/*ENZYMOLOGY/ETIOLOGY Risk Factors Substance Abuse,
Intravenous/COMPLICATIONS/*ENZYMOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).